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Oct, 2021
Diego Garcia-Borreguero, MD, PhD, Sleep Research Institute, Madrid, Spain, talks of the implications of the positive Phase III trials of daridorexant, a novel dual orexin receptor antagonist (DORAs), for the treatment of insomnia. Two pivotal Phase III studies investigating…
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Oct, 2021
For many years, GABAergic agents were the only pharmacological treatments available for patients with insomnia. Benzodiazepines and benzodiazepine receptor agonists are often used to treat insomnia, demonstrating short-term benefits on sleep onset latency and duration. However, pharmacological tolerance and cognitive side effects, amongst other associated harms, prevent their use long term. More recently, dual orexin (also known as hypocretin) receptor antagonists (DORAs) have emerged as a new treatment approach for…
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